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血管生成是指在原有的血管结构基础上,内皮细胞以出芽方式,伴随内皮细胞的迁移、扩增、管腔化,形成新的血管的过程。血管生成可分为生理性和病理性两类,病理性血管生成见于以广泛、持续的炎症坏死和纤维化为特征的各种慢性肝脏疾病,包括:慢性乙型肝炎、慢性丙型肝炎、自身免疫性肝炎和原发性胆汁性肝硬化。新血管的形成与不同病因引起的慢性肝病纤维化发展模式紧密相关[1],最终导致肝硬化组织异常血管结构的逐步形成。因此,在现代疾
Angiogenesis refers to the process of the formation of new blood vessels on the basis of the original blood vessel structure by means of the budding of endothelial cells accompanied by the migration, expansion and lumenization of endothelial cells. Angiogenesis can be divided into two categories, physiological and pathological. Pathological angiogenesis is found in a variety of chronic liver diseases characterized by extensive and persistent inflammatory necrosis and fibrosis including chronic hepatitis B, chronic hepatitis C, Immune hepatitis and primary biliary cirrhosis. The formation of new blood vessels is closely related to the development of chronic liver fibrosis caused by different etiologies [1], leading to the progressive formation of abnormal vascular structures in cirrhotic tissues. Therefore, in modern disease