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目的:分析绍兴市第七人民医院围手术期抗菌药物预防性应用的合理性,旨在为合理应用抗菌药提供参考。方法:随机抽取该院2010年1月-2014年9月入院时未感染的手术患者病历共205例,其中男103例,女102例。从预防性抗菌药物的种类、联合用药、用药频度、预防用药的时间和数量及术后感染等进行分析。结果:205例围手术期患者抗菌药物预防性应用占91.2%,其中一联用药和二联用药分别占据了69.27%和20%;青霉素类药物的使用频率最高,达48.13%,其次为头孢菌素类。术前0.5~1h给药,仅占21.39%。头孢拉定、头孢呋辛和头孢地嗪的药物利用指数(DUI)均大于1,用药存在不合理性。结论:应加强围手术期预防性抗菌药物使用的管理和监督,强化临床医师合理用药。
Objective: To analyze the rationality of prophylactic use of perioperative antibiotics in the Seventh People’s Hospital of Shaoxing City, in order to provide a reference for rational use of antibacterials. Methods: A total of 205 cases of surgical patients who were not infected at hospital admission from January 2010 to September 2014 were randomly selected, including 103 males and 102 females. From the types of preventive antimicrobial agents, combination therapy, frequency of medication, time and quantity of preventive medication and postoperative infection were analyzed. Results: The prophylactic use of antimicrobial agents was 91.2% in 205 perioperative patients, of which 69.27% and 20% were used in combined therapy and in combination therapy. The most frequent use of penicillin was 48.13%, followed by cephalosporin Class. 0.5 ~ 1h before surgery, accounting for only 21.39%. Cefradine, cefuroxime and cefodizime drug use index (DUI) were greater than 1, there is irrational medication. Conclusion: The management and supervision of perioperative prophylactic antimicrobial use should be strengthened and the rational use of drugs by clinicians should be strengthened.