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目的：研究转化生长因子β1（transforming growth factor-β1，TGFβ1）、缺氧诱导因子-1α（hypoxia inducible factor-1α，HIF-1α）在唾液腺黏液表皮样癌（mucoepidermoid carcinoma，MEC)中的表达和相关性。方法应用免疫组织化学SP法检测25例正常唾液腺组织、36例唾液腺黏液表皮样癌（20例高分化、16例低分化）中 TGFβ1和 HIF-1α的表达。结果 TGFβ1和 HIF-1α的阳性表达率在正常唾液腺组织、高分化MEC及低分化MEC中的表达均依次增强，组间差异均有统计学意义，P＜0.05；MEC中 TGFβ1随着HIF-1α表达的增强而升高，P＜0.05。结论 TGFβ1和HIF-1α的高表达在唾液腺黏液表皮样癌的分化及增殖过程中可能起重要作用。“,”Objective To investigate the expression and correlation of transforming growth factor-β 1 (TGF β 1) and hypoxia inducible factor-1 α (HIF-1 α) in salivary gland mucoepidermoid carcinoma(MEC). Methods The expression of TGFβ1 and HIF-1α in 25 cases normal salivary tissues and 36 cases MEC (20 cases with well differentiation and 16 cases with poor differentiation) were detected by the streptavidin-peroxidase (SP) immunohistochemical method. Results Positive expression rate of TGF β 1 and HIF-1 α enhanced in normal salivary gland tissue, well-differentiated MEC tissue and poorly- differentiated MEC tissues stepply P <0.05;TGFβ1 tended to depend on HIF-1α expression levels in MEC P <0.05. Conclusion The high expression of TGFβ1 and HIF-1α is considered to play an important role in cell differentiation and proliferation of MEC.