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目的①观察康妇特栓对细菌性阴道病(bacterialvaginosis,BV)的疗效;②了解BV时阴道菌群情况。方法对106‘例BV患者采用多中心、前瞻性、将康妇特与甲硝唑进行随机对照研究,观察患者症状、体征及实验室检查等方面的变化,并在初诊和第1次随访时进行阴道分泌物需氧菌培养。结果①大多数的BV患者有白带增多、白带异常的症状,检查时发现黄色分泌物占60·4%,胺试验阳性者大于80·0%,pH值绝大多数>4·5,线索细胞均阳性。②实验组与对照组比较,在第1次随访时两组患者症状明显改善,症状、体征及实验室检查均无明显差异(P>0·05),总有效率分别为92·0%与86·0%(P>0·05),两组无统计学差异。第2次随访时实验组的分泌物形状及清洁度比对照组有明显改善(P=0·023及0·001),且总有效率明显高于对照组(100·0%vs92·5%,P=0·002),患者满意程度也优于对照组(P=0·002)。③BV患者的阴道内以大肠杆菌为主,其次为甲类溶血链球菌、粪肠球菌、不动杆菌、棒状杆菌、草绿链球菌、表皮葡萄球菌。结论①应提高对BV的认识,积极予以治疗;②康妇特在疗效上明显优于甲硝唑。
Objective ① To observe the curative effect of Kangfushitiao on bacterial vaginosis (BV); ② to understand the vaginal flora of BV. Methods A total of 106 patients with BV were treated with multiple centers and prospectively. Randomized controlled trials of Kangfute and metronidazole were performed. The changes of symptoms, signs and laboratory tests were observed. At the time of first visit and the first follow-up Vaginal secretion of aerobic culture. Results ① Most of the patients with BV had the symptoms of leucorrhea and vaginal discharge abnormalities. The inspection showed that yellow secretions accounted for 60.4%, amine test was more than 80.0%, pH values were mostly> 4.5, Are positive. ② Compared with the control group, the symptoms of the two groups at the first follow-up were significantly improved, with no significant difference in symptoms, signs and laboratory tests (P> 0.05), the total effective rates were 92.0% and 86.0% (P> 0.05), there was no significant difference between the two groups. At the second follow-up, the shape and cleanliness of the secretions in the experimental group were significantly improved (P = 0.023 and 0.001), and the total effective rate was significantly higher than that of the control group (100.0% vs 92.5% , P = 0.002). Patients’ satisfaction was also better than that of the control group (P = 0.002). ③ BV patients with vaginal Escherichia coli mainly, followed by Group A hemolytic streptococcus, Enterococcus faecalis, Acinetobacter, Corynebacterium, Streptococcus viridans, Staphylococcus epidermidis. Conclusions ①We should raise the awareness of BV and actively treat it. ② Kangfute is superior to metronidazole in efficacy.