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目的 评价血管紧张素Ⅱ受体拮抗剂对高血压病患者左室重构的影响。方法 应用血管紧张素Ⅱ受体拮抗剂 (氯沙坦 ) 5 0mg/日 ,疗程 6个月 ,观察临床疗效 ,通过M型和多普勒超声心动图 (UCG)的观察对高血压病患者左室重构的影响。结果 治疗前后比较 ,SBP、DBP均明显降低 ,LVST、PWT明显降低 ,LVM和LVMI减轻 (P <0 .0 5 )。结论 长期服用血管紧张素Ⅱ受体拮抗剂可使原发性高血压患者的左室重构发生逆转
Objective To evaluate the effect of angiotensin Ⅱ receptor antagonist on left ventricular remodeling in patients with essential hypertension. Methods The angiotensin Ⅱ receptor antagonist (losartan) 50 mg / day was given for 6 months. The clinical effect was observed. M and Doppler echocardiography (UCG) Impact of room remodeling. Results Before and after treatment, SBP and DBP were significantly decreased, LVST and PWT were significantly decreased, LVM and LVMI were reduced (P <0.05). Conclusion Long-term administration of angiotensin Ⅱ receptor antagonist can reverse left ventricular remodeling in patients with essential hypertension