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目的：分析医院综合重症监护病房（GICU ）医院获得性肺炎（HAP）感染菌株特点及耐药情况。方法回顾性分析GICU收治61例 HAP患者的感染菌株及其对抗菌药物耐药性。结果61例H A P患者中，共检出213株菌。革兰阴性杆菌99株（46.5％），以鲍曼不动杆菌、肺炎克雷伯菌、铜绿假单胞菌和大肠埃希菌为主；革兰阳性球菌81株（38.0％），以肠球菌、金黄色葡萄球菌、表皮葡萄球菌和溶血葡萄球菌为主；真菌33株（15.5％），以白色念珠菌和非白色念珠菌为主。鲍曼不动杆菌株较多对抗生素多重耐药，未发现耐万古霉素的肠球菌株和葡萄球菌株。结论应根据细菌病原学及抗菌药物耐药性，合理选择抗菌药物，控制GICU内 HAP感染的发生，减少耐药菌的出现。“,”Objective To analyze the infected strains and bacterial resistance of hospital acquired pneumonia(HAP) in general intensive care unit (GICU ) .Methods Data of isolated infected strains and their resistance to anti‐biotics in 61 patients with HAP in GICU were retrospectively analyzed .Result A total of 213 bacteria strains was isolated in 61 HAP patients ,of which 99 (46.5% ) strains were gram‐negative bacteria ,81(38.0% ) strains were gram‐positive bacteria and 33 (15.5% ) strains were fungus .Gram‐negative bacteria included mainly acinetobacter baumannii , klebsiella pneumoniae ,pseudomonas aeruginosa and escherichia coli .Gram‐positive bacteria included mainly enterococcus ,staphylococcus aureus ,epidermis staphylococcus and hemolytic staphylococci . Fungus included mainly candida albicans and non‐candida albicans .Acinetobacter baumannii strains tended to have multiple drug resistance .No strain of staphylococcus and enterococcus resistant to vancomycin was found . Conclusion According to bacterial etiology characteristics and bacterial resistance ,antibiotics should be reasonably selected to control HAP in GICU and reduce the occurence of drug‐resistant bacteria .