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作者用过氧化氢灭活提纯百日咳毒素所组成的百日咳无细胞菌苗(PTxd)给15～30月龄的幼儿接种,评价其免疫原性和副作用。将101名在婴儿期接种过3针白喉、破伤风类毒素、百日咳菌苗混合制剂(DTP)的幼儿分为3组,分别肌肉注射用氢氧化铝吸附10μg(n=33)或50μg(n=34)的PTxd和DTP(n=34)。于接种后24小时和7天测量体温和检查局部反应;测定免疫前和免疫后
The author used hydrogen peroxide inactivated purified pertussis toxin composed of pertussis acellular bacterin (PTxd) to 15 to 30-month-old children vaccination, evaluation of their immunogenicity and side effects. Totally 101 infants who had been vaccinated with 3 doses of diphtheriae, tetanus toxoid and pertussis vaccine (DTP) during infancy were divided into 3 groups and each group was intramuscularly injected with aluminum hydroxide (10 μg, n = 33) or 50 μg = 34) of PTxd and DTP (n = 34). Body temperature was measured at 24 hours and 7 days after inoculation and examined for local reactions; pre-immunization and post-immunization