Inhibitory Effect of TanshinoneⅡA on TGF-β1-induced Cardiac Fibrosis

• 作 者: Daixing ZHOU Zhihui LI Liwei Z
• 机 构: DepartmentofEmergencyMedicine
• 出 处: 华中科技大学学报：医学英德文版
• 发表日期: 2012年6期
• 关键词: tanshinoneⅡA TRANSFORMING GROWTH FACTOR β1 SMADS CONNECTIVE tissue GROWTH FACTOR
• 基金项目: supported by a grant from the Natural Science Foundation of Hubei Province of China(Nos.2009CDB092,2007ABA272)

This study examined the effect of tanshinoneⅡA (TSNⅡA) on the cardiac fibrosis induced by transforming growth factor β1 (TGF-β1) and the possible mechanisms. Cardiac fibroblasts were isolated from cardiac tissues of neonatal Sprague-Dawley (SD) rats by th