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对急性心肌梗塞（AMI）患者按是否并发梗塞后心绞痛、梗塞延展和心力衰竭分为24倒无并发症组和11例有并发症组，采用放射免疫方法检测不同时间血浆内皮素－1（ET－1）浓度。结果显示：与正常对照组（1．60±0．43pg／ml）比较，无并发症组和有并发症组AMI患者血浆ET－1浓度在入院即刻已经升高（2．70±0．46pg／ml和2．98±0．50pg／ml，均P＜0．01），无并发症组到发病后第3天降低到正常（1．82±37pg／ml．P＞0．05）．而有并发症组一直持续到观察终点第7天仍然比较高（3．60±0．41pg／ml，P＜0.01）。提示：AMI患者血浆ET－1浓度持续升高反映了心肌持续缺血或心功能减退。
Patients with acute myocardial infarction (AMI) according to whether complicated with post-infarction angina pectoris, infarction extension and heart failure were divided into 24 non-complication group and 11 patients with complications. Radioimmunoassay was used to detect plasma endothelin-1 (ET -1) concentration. The results showed that compared with the normal control group (1.60 ± 0.43pg / ml), plasma ET-1 concentrations in AMI patients without complication and complications group had increased immediately after admission (2.70 ± 0.46pg / Ml and 2.98 ± 0.50pg / ml, all P <0.01), and no complication decreased to normal on the 3rd day after onset (1.82 ± 37pg / ml, P> 0.05). The complication group remained high until the end of observation day 7 (3.60 ± 0.41 pg / ml, P <0.01). Hint: Continuous plasma ET-1 levels in patients with AMI reflect persistent myocardial ischemia or impaired cardiac function.