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作者分析105例中枢神经系统(CNS)淋巴瘤的临床特征、组织学和预后因素,介绍了 CNS 淋巴瘤的诊断、治疗和 CNS 预防性治疗的作用。105例中94例是确诊的、11例是可疑脑膜或实质性 CNS 淋巴瘤,前者为脑脊液(CSF)细胞学、尸检或CNS 组织活检证实,后者符合以下标准:①已有颅外淋巴瘤;②伴不明原因的 CNS 症状或休征;③“可疑”CSF 细胞学结果或放射核素或 CT 或脑血管造影证实 CNS 结构异常;④全脑放疗和/或鞘内(IT)化疗使症状缓解或改善。其中8例是原发性、97例是继发性 CNS 淋巴瘤。
The authors analyzed the clinical features, histology and prognostic factors of 105 patients with central nervous system (CNS) lymphoma and introduced the role of CNS lymphoma diagnosis and treatment and CNS prophylactic treatment. Of 105 cases, 94 were diagnosed and 11 were suspected meninges or substantial CNS lymphoma. The former was CSF cytology, autopsy or CNS biopsy confirmed that the latter met the following criteria: ① There are extracranial lymphoma ; ② symptoms or signs of CNS with unexplained causes; ③ “suspicious” CSF cytology findings or radionuclide or CT or cerebral angiography to confirm structural abnormalities in the CNS; and ④ whole brain radiotherapy and / or intrathecal (IT) chemotherapy to cause symptoms Ease or improve. Of these, 8 were primary and 97 were secondary CNS lymphoma.