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目的探讨普伐他汀对老年单纯收缩期高血压(ISH)患者的血压及血管内皮功能的影响。方法选取老年ISH患者96例,随机分为对照组和治疗组,对照组给予苯磺酸氨氯地平5mg,每日1次口服,治疗组在此基础上加用普伐他汀20mg,每晚1次口服,疗程1年。分别在治疗前后监测血压、脉压(PP)、血脂的变化,测定血浆一氧化氮(NO)和内皮素-1(ET-1)水平的变化,并采用超声法检测内皮依赖性血管舒张功能(FMD)。结果治疗1年后,两组收缩压(SBP)、舒张压(DBP)及PP与治疗前比较,差异均有统计学意义(P<0.05),治疗组SBP及PP与对照组比较,差异有统计学意义(P<0.05),DBP差异无统计学意义(P>0.05);治疗后两组血脂指标比较,差异有统计学意义(P<0.05);治疗后治疗组NO的水平、FMD明显升高,ET-1的水平明显下降,且与对照组比较差异均有统计学意义(P<0.05)。结论普伐他汀对老年ISH患者有协同降压的作用,且可缩小PP、降低血脂,改善血管内皮功能。
Objective To investigate the effect of pravastatin on blood pressure and endothelial function in elderly patients with isolated systolic hypertension (ISH). Methods A total of 96 elderly patients with ISH were randomly divided into control group and treatment group. The control group was treated with amlodipine besylate 5 mg orally once daily. On the basis of this, pravastatin 20 mg and night 1 Oral, treatment for 1 year. The changes of blood pressure, pulse pressure (PP) and blood lipids were measured before and after treatment. The levels of plasma nitric oxide (NO) and endothelin-1 (ET-1) were measured. The endothelium-dependent vasodilation (FMD). Results After 1 year of treatment, the SBP, DBP and PP in the two groups were significantly different from those before treatment (P <0.05). There was significant difference in the SBP and PP between the treatment group and the control group (P <0.05). There was no significant difference in DBP between the two groups (P> 0.05). After treatment, there was significant difference in serum lipids between the two groups (P <0.05) (P <0.05), and the level of ET-1 decreased significantly compared with the control group (P <0.05). Conclusion Pravastatin has synergistic antihypertensive effects on elderly patients with ISH, and can reduce PP, lower blood lipids and improve endothelial function.