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目的探讨老年人群骨密度(BMD)与25-羟维生素D(25OHD)的相关性,为防治老年人骨质疏松提供可靠的临床理论依据。方法选择我院2013年3月至2014年10月,年龄大于60岁的老年患者的临床资料共647例。采用双能X线骨密度仪,进行骨密度测定。将骨密度分为骨质疏松组、低骨量组、骨密度正常组,对比各组的年龄、身高、体重及血清中25羟维生素D的含量,并将骨密度与以上各指标进行相关性分析。结果老年患者的身高、体重及25OHD均随着骨密度的升高而增加,差异有统计学意义,P<0.0001;且骨密度均与身高、体重及25OHD分别呈相关,相关系数分别为0.303、0.174和0.25;多元线性回归分析显示,身高、体重及25OHD分别是骨密度的影响因素。结论老年患者中的身高、体重及25OHD均是骨密度的影响因素,检测血清中25OHD的含量可为老年人防治骨质疏松提供可靠的临床依据。
Objective To investigate the correlation between BMD and 25-OHD in the elderly and to provide a reliable clinical evidence for the prevention and treatment of osteoporosis in the elderly. Methods A total of 647 elderly patients aged above 60 years old were selected from March 2013 to October 2014 in our hospital. Using dual-energy X-ray absorptiometry, bone mineral density was measured. The bone mineral density was divided into osteoporosis group, low bone mass group and normal bone mineral density group. The age, height, body weight and content of 25 hydroxyl vitamin D in each group were compared. BMD was compared with the above indexes analysis. Results The height, weight and 25OHD of elderly patients increased with the increase of BMD, the difference was statistically significant (P <0.0001). The BMD was correlated with height, weight and 25OHD respectively, the correlation coefficients were 0.303, 0.174 and 0.25; Multiple linear regression analysis showed that height, weight and 25OHD were the influencing factors of bone mineral density respectively. Conclusion The height, weight and 25OHD in elderly patients are the influencing factors of bone mineral density. Detecting the content of 25OHD in serum can provide a reliable clinical basis for prevention and treatment of osteoporosis in the elderly.