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目的总结CLH的临床病理特点,以减少误诊。方法选取CLH病例32例,分为三组进行回顾性病例分析。第1组:单部位病例,具有“特征性的”肉眼及临床特点;第二组:单部位病例,但无以上特点;第3组:多部位病例。结果 1.第一组病例除具有“特征性的”肉眼及临床特点外,亦具有特征性的镜下特点。第三组病例病史较为复杂。2.三组病例镜下形态及免疫形态的共同点:表皮及皮肤附属器无破坏;病变细胞种类杂,除T、B细胞外混杂组织细胞、浆细胞、CD30阳性的活化大细胞;Ki-67大部分病例可达到20-40%。3第一、二组病例以T-CLH居多,第三组病例全部为B-CLH病例。
Objective To summarize the clinical and pathological features of CLH to reduce misdiagnosis. Methods 32 cases of CLH were selected and divided into three groups for retrospective case analysis. Group 1: Single-site cases with “characteristic” macroscopic and clinical features; Group 2: Single-site cases but no above characteristics; Group 3: Multi-site cases. In addition to the first group of patients with “characteristic ” naked eye and clinical features, but also has a characteristic microscopic features. The third group of cases history is more complicated. The three groups of patients under microscopic morphology and immune morphology common: no damage to the epidermis and skin appendages; lesions of miscellaneous types of cells, in addition to T, B cells mixed with tissue cells, plasma cells, CD30-positive activated macrophages; Ki- 67 Most cases can reach 20-40%. 3 The first and second groups of cases are mostly T-CLH, the third group of cases are all B-CLH cases.