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Objective:To study the effect of atorvastatin on atherosclerotic rabbits.Methods:A total of 60 Now Zealand male rabbits were randomly divided into the normal group,model group and atorvastatin group.The replication rabbit atherosclerotic model with immune injury combined with a high fat diet feeding was used.All rabbits were sacrificed after 3 months.TLR4 and NF-κB p65 were observed by HE staining,immunohistochemistry and western blotting.Results: The expression of TLR4,NF- k B p65 were significantly increased in the model group compared widi the normal group.The expression of TI.R4 and NK- k B p65 decreased significantly in the atorvastatin group,and there was no difference compared with the normal group.Conclusions: The effect of atorvastatin on adierosclerosis may be achieved by the inhibition of the expression of TLK4 and NF-κB p65.
Objective: To study the effect of atorvastatin on atherosclerotic rabbits. Methods: A total of 60 Now Zealand male rabbits were randomly divided into the normal group, model group and atorvastatin group. Replication rabbit atherosclerotic model with immune injury combined with a high fat diet feeding was used. All rabbits were sacrificed after 3 months. TLR4 and NF-κB p65 were observed by HE staining, immunohistochemistry and western blotting. Results: The expression of TLR4, NF-κ B p65 were significantly increased in the model group compared widi the normal group. The expression of TI.R4 and NK-k B p65 decreased significantly in the atorvastatin group, and there was no difference compared with the normal group. Conclusions: The effect of atorvastatin on adierosclerosis may be achieved by the inhibition of the expression of TLK4 and NF-κB p65.