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目的探讨Ⅱ型糖尿病（ＮＩＤＤＭ）尿白蛋白排泄量与视网膜病变的关系及其防治方法。方法对２１８例ＮＩＤＤＭ进行了２４ｈ尿白蛋白排泄量测定和眼底检查，同时测定糖基化血红蛋白（ＨｂＡ１ｃ）含量，并记录血压及病程。结果糖尿病肾病（ＤＮ）的发生率为４１．３％，其中微量蛋白尿为３０．３％，持续蛋白尿１１％。糖尿病视网膜病变（ＤＲ）的发生率为５０．９％，其中背影型视网膜病变（ＢＤＲ）占４２．４％，增殖型视网膜病变（ＰＤＲ）８．７％。正常蛋白尿组３６．７％伴ＢＤＲ，３．９％伴ＰＤＲ；微量蛋白尿组５６．４％伴ＢＤＲ，１０．３％伴ＰＤＲ；持续蛋白尿组５０％有ＢＤＲ，３３．３％伴ＰＤＲ。微量蛋白尿组与正常蛋白尿组比较ＤＲ的发生率明显增高（Ｐ＜０．０１），大量蛋白尿组与微量蛋白尿组比较ＤＲ的发生率明显增高，但差异无显著性（Ｐ＞０．０５），动脉压（ＭＡＰ）分别为１３．５７±１．８１和１２．８９±１．９９ｋＰａ（Ｐ＞０．０５）；持续蛋白尿组与微量蛋白尿组比较ＭＡＰ分别为１５．４５±３．１４和１３，５７±１．８１（Ｐ＜０．０２５）。结论糖尿病病程、血糖控制不良、高血压是ＤＮ和ＤＲ发生发展的重要危险因素
Objective To investigate the relationship between urinary albumin excretion and retinopathy in type 2 diabetes mellitus (DM) and its prevention and treatment. Methods 218 urinary albumin excretion and fundus examination were performed on 218 cases of NIDDM. The content of HbA1c was also measured, and the blood pressure and course of disease were recorded. Results The incidence of diabetic nephropathy (DN) was 41.3%, of which microalbuminuria was 30.3% and persistent proteinuria was 11%. The incidence of diabetic retinopathy (DR) was 50.9%, with 42.4% for back-type retinopathy (BDR) and 8.7% for proliferative-retinopathy (PDR). 36.7% of patients with normal proteinuria with BDR, 3.9% with PDR; 56.4% with albuminuria with BDR, 10.3% with PDR; 50% with persistent proteinuria with BDR, 33.3% with PDR. The incidence of DR in microalbuminuria group was significantly higher than that in normal proteinuria group (P <0.01), and the incidence of DR in mass proteinuria group and microalbuminuria group was significantly higher than that in normal proteinuria group (P <0.01) .05) and arterial pressure (MAP) were 13.57 ± 1.81 and 12.89 ± 1.99 kPa, respectively (P> 0.05). MAP in persistent proteinuria group and microalbuminuria group was 15.45 ± 3.14 and 13, 57 ± 1.81 (P <0.025). Conclusions Diabetes mellitus, poor glycemic control and hypertension are important risk factors for the development of DN and DR