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目的对比分析Sp1在胃癌、不典型增生及正常组织中的蛋白表达差异,并探讨Sp1蛋白表达与临床病理特征的相关性。方法应用免疫组化的方法,检测并对比胃癌、不典型增生及正常组织中Spl蛋白的表达。结果 Spl蛋白在胃癌组织中阳性表达率高达58.7%,显著高于不典型增生(23.8%)及正常组织(14.3%)中Spl的阳性表达率,差异有统计学意义(P<0.05);Sp1蛋白阳性表达与肿瘤浸润深度及肿瘤分期、淋巴结转移之间具有相关性。结论 Sp1表达在胃癌的发生、发展中具有一定作用,可作为胃癌预后评价的独立影响因子,具有一定的实用价值。
Objective To compare and analyze the expression of Sp1 in gastric cancer, atypical hyperplasia and normal tissues, and to explore the correlation between Sp1 protein expression and clinicopathological features. Methods Immunohistochemical method was used to detect and compare the expression of Spl protein in gastric cancer, atypical hyperplasia and normal tissues. Results The positive rate of Spl protein in gastric carcinoma was 58.7%, which was significantly higher than that in atypical hyperplasia (23.8%) and normal tissue (14.3%), the difference was statistically significant (P <0.05) Protein positive expression and tumor invasion depth and tumor stage, lymph node metastasis has a correlation. Conclusion The expression of Sp1 may play an important role in the development and progression of gastric cancer, which may be used as an independent influencing factor for the prognosis of gastric cancer. It has some practical value.