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目的比较α-2b干扰素局部注射与肌内注射预防尖锐湿疣复发的疗效。方法265例尖锐湿疣患者为第一组,给予CO2激光治疗。经CO2激光治疗后复发的109例患者随机分为第二组(54例)和第三组(55例),第二组用α-2b干扰素300万U肌内注射,隔日1次,共10次;第三组用α-2b干扰素300万U局部注射于创面基底部及周围,隔日1次,共10次。随访3个月后评估复发率。结果第一组复发率为42.7%,第二组复发率为46.2%,第三组复发率为15.4%。结论α-2b干扰素局部注射能有效预防尖锐湿疣复发,值得临床应用推广。
Objective To compare the efficacy of local injection of α-2b interferon and intramuscular injection to prevent recurrence of condyloma acuminatum. Methods 265 patients with genital warts as the first group, giving CO2 laser treatment. 109 patients relapsed after CO2 laser treatment were randomly divided into the second group (54 cases) and the third group (55 cases), and the second group injected intramuscularly with 3 million U-2b interferon every other day for a total of 10 times; the third group with α-2b interferon 3000000 U local injection at the base of the wound and the surrounding every other day, a total of 10 times. Recurrence rate was assessed after 3 months of follow-up. Results The recurrence rate was 42.7% in the first group, 46.2% in the second group, and 15.4% in the third group. Conclusion The local injection of interferon alfa-2b can effectively prevent the recurrence of condyloma acuminatum, which is worthy of clinical application.