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目的评估腺苷脱氧酶(ADA)在诊断结核性胸水中检验价值。方法回顾性分析单独ADA检测与ADA联合CEA(癌胚抗原)检测在结核性胸水诊断中的特异性及敏感性。结果单独ADA检查诊断结核性胸腔积液的符合率为90.1%(109/121),其中9例患者肺结核合并肺癌,5例诊断为肺癌,漏诊4例。CEA联合检验组中CEA平均表达水平明显高于结核性胸腔积液组,ADA的检验敏感性及特异性均低于结核组患者。结论检验ADA在结核性胸水中具有高度敏感性及特异性,鉴别癌性胸水中起到非常重要的作用,值得广泛应用。
Objective To evaluate the diagnostic value of adenosine deoxygenase (ADA) in the diagnosis of tuberculous pleural effusion. Methods The specificity and sensitivity of ADA alone and ADA combined with carcinoembryonic antigen (CEA) in the diagnosis of tuberculous pleural effusion were retrospectively analyzed. Results The coincidence rate of ADA alone diagnosed tuberculous pleural effusion was 90.1% (109/121). Among them, 9 cases were diagnosed as lung cancer by pulmonary tuberculosis, 5 cases were diagnosed as lung cancer, and 4 cases were missed. The average CEA expression level in the CEA combined test group was significantly higher than that in the tuberculous pleural effusion group. The sensitivity and specificity of ADA test were lower than those in the tuberculosis group. Conclusion ADA test in tuberculous pleural effusion with a high sensitivity and specificity, differential diagnosis of pleural effusion play a very important role, it is widely used.