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子宫内膜癌是女性生殖系统常见的恶性肿瘤,是导致女性死亡的重要因素。近年来世界范围内发病率明显上升,且趋于年轻化,早期诊断和治疗对改善患者预后至关重要。但截至目前仍缺乏敏感而特异的血清学标记物。近来研究发现,人附睾蛋白4(HE4)在子宫内膜癌组织中高表达,而在正常内膜组织及内膜良性病变中不表达或低表达,HE4是否可作为子宫内膜癌的早期诊断和预后的指标备受关注。现就HE4在子宫内膜癌的诊断和预后评估等方面的临床应用价值进行综述。
Endometrial cancer is a common malignant tumor of the female reproductive system and is an important factor leading to the death of women. In recent years, the incidence of the world increased significantly, and tend to be younger, early diagnosis and treatment to improve the prognosis of patients is essential. However, up to now, there is a lack of sensitive and specific serological markers. Recently, it was found that human epididymal protein 4 (HE4) is overexpressed in endometrial carcinoma and not expressed or expressed in normal endometrial and endometrial benign lesions. Whether HE4 can be used as an early diagnosis of endometrial cancer and Prognostic indicators have drawn much attention. The clinical application of HE4 in the diagnosis and prognosis of endometrial cancer is reviewed.