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1965年Berggard等首先从肾脏病人(Wilson病和慢性镉中毒)尿中分离出β_2M(β_2-microg-lobulin)。近年来,它在临床医学领域内引起了广泛的重视。它不仅是评价肾病患者肾功能敏感的指标,而且在类风湿性关节炎、系统性红斑狼疮、Sjogren等自身兔疫性疾病以及肿瘤、肝病中也得到应用。国内
In 1965 Berggard et al first isolated β_2M (β_2-microg-lobulin) from urine of kidney patients (Wilson’s disease and chronic cadmium poisoning). In recent years, it has drawn wide attention in the field of clinical medicine. It is not only an indicator of kidney function sensitivity in patients with nephropathy, but also in autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, Sjogren, and tumors and liver diseases. domestic