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氟苯噁唑(Fluconazole)是一种新型的抗霉菌药物,在玻璃体中有明显的抗霉菌活性。它能与血浆蛋白结合而分布到各脏器中,并能有效地进入到眼组织内。氟苯噁唑口服吸收好,由肾脏排出半衰期长,毒性低。从理论上讲,是一种良好的抗霉菌药物。患者,男性,63岁。患直肠癌已有腹部及肺部转移。腹部肠造瘘术后,应用广谱抗生素并行化疗。患者有霉菌性口腔炎,因右眼视物模糊来眼科检查。右眼:视力:20/50,前房可见炎症细胞,玻璃体混浊并有细胞,视盘处可见白色浓厚浸润。左眼弱视,视力:20/60,前房无炎症,视网膜近周边部可见白色活动性病灶并累及玻璃体。根据患者恶性肿瘤及化疗病史,以及白色念珠菌口
Fluconazole is a new antifungal drug that has significant antimycotic activity in the vitreous. It can be combined with plasma proteins and distributed to various organs, and can effectively enter the eye tissue. Oxyfluorfenoxazole oral absorption, by the kidneys discharge long half-life, low toxicity. In theory, it is a good anti-mold medicine. Patient, male, 63 years old. Rectal cancer has been abdominal and lung metastases. Abdominal enterostomy, the application of broad-spectrum antibiotics in parallel with chemotherapy. Patients with fungal stomatitis, ophthalmology due to blurred vision of the right eye. Right eye: visual acuity: 20/50, anterior chamber visible inflammatory cells, vitreous opacity and cells, the disc visible white thick infiltration. Left amblyopia, visual acuity: 20/60, anterior chamber no inflammation, peripheral retinal visible white activity lesions and involving the vitreous. According to the patient’s history of malignancy and chemotherapy, and Candida albicans mouth