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目的探讨金双歧在慢性深度黄疸肝炎治疗中的具体作用及疗效。方法收集如下血标本:慢性深度黄疸乙型肝炎患者80例,配对设计,随机分为对照组、治疗组。对照组常规护肝治疗,治疗组在此基础上加用金双歧治疗。治疗前后分别采取静脉血3ml。采血当日送检肝功能。分别用鲎实验改良基质法进行内毒素定量测定,放射免疫方法(RIA)测定肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)。结果金双歧治疗组与对照组相比,内毒素、TNF-α、IL-6与总胆红素(TBIL)水平下降,其差异有显著性意义(P <0.05),并且,治疗组并发症发生较少。结论金双歧能减轻慢性深度黄疸肝炎患者的内毒素血症,降低细胞因子水平,可作为防治严重肝病的常规辅助疗法。
Objective To explore the specific effect and therapeutic effect of Jinshuangqi in the treatment of chronic jaundice hepatitis. Methods The following blood samples were collected: chronic deep jaundice hepatitis B patients 80 cases, paired design, were randomly divided into control group and treatment group. Control group conventional liver treatment, the treatment group on the basis of gold bifidobacterium treatment. Before and after treatment were taken venous blood 3ml. Blood on the day to check liver function. The levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were determined by radioimmunoassay (RIA). Results Compared with the control group, the levels of endotoxin, TNF-α, IL-6 and total bilirubin in the bifidobacterium group were significantly decreased (P <0.05), and the complication occurred in the treatment group less. Conclusion Jinshuangqi can attenuate endotoxemia and reduce the levels of cytokines in patients with chronic hepatitis caused by jaundice and can be used as a routine adjuvant therapy for the prevention and treatment of severe liver diseases.