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端粒酶作为细胞永生的基本要素 ,其活性升高是正常细胞恶性转化的关键步骤。作者用端粒重复扩增和免疫组织化学方法分别对 72例色素痣 (37例普通型和 35例增生不良型 )和 1 6例恶性黑色素瘤组织的端粒酶活性以及细胞周期时相蛋白 8Ｋｉ 67和ｒｅｐｐ86进行检测。结果显示 :端粒
As an essential element of cell immortality, telomerase activity is a key step in the malignant transformation of normal cells. The authors used telomere repeat amplification and immunohistochemical methods to detect telomerase activity in 72 cases of nevus (37 cases of common type and 35 cases of dysplasia) and 16 cases of malignant melanoma tissue, as well as cell cycle phase protein 8Ki 67 and repp86 for testing. The results show: telomeres