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目的:探讨乙醛脱氢酶2(ALDH2)基因多态性与急性冠脉综合征的相关性,为急性冠脉综合征患者的预防提供依据。方法:收集所有研究对象血液样本,包括健康体检者60例,入院确诊为急性冠脉综合征患者60例。血样采用PCR测序法进行基因多态性检测。对所有研究对象详细记录基本临床资料。所有数据分析运用SPSS 19.0统计软件进行处理。结果:泰安地区ALDH2基因型及等位基因G、A在急性冠脉综合征(ACS)组和正常组中分布具有显著性的统计学差异,ALDH2基因多态性可能是急性冠脉综合征发生的危险因素。经单因素Logistic回归分析结果提示ALDH2基因多态性、饮酒、高血压、糖尿病、既往急性心肌梗死病史以及性别与急性冠脉综合征发生的相关性,进一步经多因素Logistic回归分析结果显示年龄、饮酒、高血压、既往心肌梗死病史是急性冠脉综合征发生的独立危险因素。结论:泰安地区人口中急性冠脉综合征患者乙醛脱氢酶2基因多态性以及等位基因ALDH2*2的分布明显高于正常人群。年龄、饮酒、高血压、既往心肌梗死病史等成为影响急性冠脉综合征发生的危险因素。
Objective: To investigate the association of ALDH2 gene polymorphism with acute coronary syndrome (ACS) and to provide evidence for the prevention of ALDH2 in patients with acute coronary syndrome. Methods: All subjects were enrolled in the blood samples, including 60 healthy subjects and 60 patients admitted to hospital for acute coronary syndrome. Blood samples were analyzed by PCR for gene polymorphism. Detailed record of basic clinical data for all subjects. All data analysis using SPSS 19.0 statistical software for processing. Results: There was a significant difference in ALDH2 genotype and allele G, A between acute coronary syndrome (ACS) group and normal group in Tai’an area. ALDH2 gene polymorphism may be the cause of acute coronary syndrome Risk factors. Logistic regression analysis showed that the association of ALDH2 gene polymorphisms, alcohol consumption, hypertension, diabetes mellitus, past history of acute myocardial infarction, and gender with acute coronary syndromes was further analyzed by multivariate logistic regression analysis. Age, Alcohol consumption, high blood pressure, history of previous myocardial infarction were independent risk factors for acute coronary syndrome. Conclusion: The ALDH2 * 2 polymorphism and allele ALDH2 * 2 in patients with acute coronary syndrome in Tai’an population are significantly higher than those in normal population. Age, alcohol consumption, high blood pressure, history of previous myocardial infarction, etc., have become the risk factors influencing the occurrence of acute coronary syndrome.