【摘 要】
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目的:对比盐酸羟考酮缓释片与硫酸吗啡缓释片治疗重度癌痛的有效性及安全性.方法:75例重度癌痛患者,采用随机数字表法分为A组(38例)和B组(37例).A组患者应用盐酸羟考酮缓释片
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目的:对比盐酸羟考酮缓释片与硫酸吗啡缓释片治疗重度癌痛的有效性及安全性.方法:75例重度癌痛患者,采用随机数字表法分为A组(38例)和B组(37例).A组患者应用盐酸羟考酮缓释片治疗,B组患者应用硫酸吗啡缓释片治疗,对比两组患者治疗前后的疼痛控制情况、镇痛效果及不良反应发生情况.结果:A组患者治疗前数字疼痛评分法(NRS)为(8.52±1.20)分,B组患者为(8.60±1.30)分,对比差异无统计学意义(P＞0.05);治疗后,A组患者NRS评分为(1.85±0.50)分,B组患者为(1.90±0.55)分,A、B组治疗后NRS评分均低于治疗前,差异有统计学意义(P＜0.05),两组治疗后NRS评分对比,差异无统计学意义(P＞0.05).A组患者镇痛总有效率为94.74％,B组患者镇痛总有效率为91.89％,对比差异无统计学意义(P＞0.05).A组患者不良反应发生率为18.42％,明显低于B组的40.54％,差异具有统计学意义(P＜0.05).结论:在重度癌痛患者中应用盐酸羟考酮缓释片对疼痛的控制作用和镇痛效果与硫酸吗啡缓释片相当,但盐酸羟考酮缓释片的不良反应更少.
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