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目的观察急性心肌梗塞（ＡＭＩ）患者接受静脉溶栓治疗时，血清肌钙蛋白Ⅰ（ｃＴｎⅠ）浓度变化，探讨其对溶栓疗效的判定价值。方法选择ＡＭＩ患者５３例，２６例接受溶栓治疗。采用ＯＰＵＳ自动生化分析仪，以ＥＬＩＳＡ法测定ｃＴｎⅠ浓度。结果显示：（１）从发病到达ｃＴｎⅠ峰值时间，２２例溶栓再通组（１５．７±３．９小时）比４例溶栓未通组（２２．０±２．３１小时）及２７例未溶栓组（２６．２±１１．１小时）均明显提前（Ｐ＜０．０５）。（２）血清ｃＴｎⅠ峰值水平在溶栓再通组（３２８．０±２４５．２μｇ／Ｌ）比溶栓未通组（１７０．５±５０．２μｇ／Ｌ）及未溶栓组（１３０．７３±１００．０３μｇ／Ｌ）明显增高（Ｐ＜０．０１）。（３）以ｃＴｎⅠ峰值到达时间≤１８小时判定ＡＭＩ后溶栓再通，其敏感性、准确性（分别为７２．７％和７３．１％），均高于ＣＫ－ＭＢ≤１４小时（分别为６３．６％和６５．４％），特异性二者相同（均为７５％）。结论血清ｃＴｎⅠ水平，在ＡＭＩ溶栓再通患者中峰值时间前移，其≤１８小时对ＡＭＩ溶栓再通具有一定的判定价值。
Objective To observe the change of serum troponin Ⅰ (cTn Ⅰ) concentration in patients with acute myocardial infarction (AMI) receiving intravenous thrombolysis and to evaluate the value of thrombolytic therapy. Methods 53 patients with AMI were selected and 26 received thrombolysis. The OPUS automatic biochemical analyzer was used to determine the concentration of cTnI by ELISA. The results showed that: (1) From the onset of peak cTnI time, 22 cases of thrombolysis recanalization group (15.7 ± 3.9 hours) than 4 cases of failed thrombolysis group (22.0 ± 2.31 hours) and 27 Cases without thrombolysis group (26.2 ± 11.1 hours) were significantly advanced (P <0.05). (2) Serum cTnI peak levels were significantly higher in patients receiving thrombolysis (328.0 ± 245.2 μg / L) than those without thrombolysis (170.5 ± 50.2 μg / L) and those without thrombolysis (130.73 ± 100.03μg / L) was significantly higher (P <0.01). (3) The sensitivity and accuracy (72.7% and 73.1%, respectively) of thrombolytic recanalization after AMI were determined by cTnI peak arrival time ≤18 hours were higher than CK-MB≤14 hours 63.6% and 65.4% respectively) with the same specificity (both 75%). Conclusions The level of serum cTn Ⅰ in patients with AMI thrombolysis recanalization peak time forward, its ≤ 18 hours on AMI thrombolysis recanalization has a certain value.