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目的探讨单项抗-HEV-IgG阳性对急性戊型肝炎的临床诊断价值。方法收集连续收治的非甲～非丁型急性肝炎患者168例,其中仅抗-HEV-IgG阳性而抗-HEV-IgM阴性者53例,而抗-HEV-IgM/抗-HEV-IgG阳性115例,分析比较了他们的年龄、肝功能、肝脾B型超声波检查情况。结果在168例非甲～非丁型急性肝炎患者中,有31.55%(53/168)患者从第1病周至第6病周以上仅检测到抗-HEV-IgG阳性,而抗-HEV-IgM阴性;68.45%(115/168)患者抗-HEV-IgM/抗-HEV-IgG阳性。53例单项抗-HEV-IgG阳性者与115例抗-HEV-IgM/抗-HEV-IgG阳性者的年龄、肝功能和肝脾B型超声波检查指标的比较,两组之间均无显著性差异(P=0.311～0.976)。结论使用人工合成的戊型肝炎病毒开放阅读区1和2编码的重组多肽抗原检测抗-HEV-IgM和IgG,如果单项抗-HEV-IgG阳性、有急性病毒性肝炎的肝功能改变,并能排除其他病因者,可以临床诊断急性戊型肝炎。
Objective To investigate the clinical value of anti-HEV-IgG positive for acute hepatitis E in patients. Methods A total of 168 consecutive patients with non-A-type acute hepatitis were enrolled in this study. Among them, 53 were anti-HEV-IgG positive and anti-HEV-IgM negative, while 115 were anti-HEV-IgM / anti-HEV-IgG Cases, analysis and comparison of their age, liver function, liver and spleen type B ultrasound examination. Results Of the 168 patients with non-A-type acute hepatitis, 31.55% (53/168) of patients had anti-HEV-IgG positive only from week 1 to week 6, while anti-HEV-IgM Negative; 68.45% (115/168) patients were positive for anti-HEV-IgM / anti-HEV-IgG. There were no significant differences in the age, liver function, and B-mode ultrasound in 53 cases of single anti-HEV-IgG positive and 115 cases of anti-HEV-IgM / anti-HEV-IgG positive Difference (P = 0.311 ~ 0.976). Conclusions Anti-HEV-IgM and IgG were detected using recombinant polypeptide antigens encoded by the synthetic hepatitis E viral open reading regions 1 and 2 and had altered liver function in acute viral hepatitis if single anti-HEV-IgG was positive and Excluding other causes, clinical diagnosis of acute hepatitis E.