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目的 探讨食管小细胞未分化癌的临床特点、治疗及预后。方法 对 75例食管小细胞未分化癌患者进行回顾性分析。男性 5 8例 ,女性 17例。食管颈段 2例 ,胸上段 11例 ,胸中段 46例 ,胸下段 16例。 37例肿瘤长度≤ 5cm ,38例 >5cm。单纯手术 16例 (2 1.3% ) ,单纯化疗 5例 (6 .7% ) ,单纯放射治疗 4例 (5 .3% ) ,手术 +化疗 32例 (4 2 .6 % ) ,化疗 +放射治疗 14例 (18.0 % ) ,手术 +化疗+放射治疗 4例 (5 .3% )。结果 单纯手术者、单纯化疗者、单纯放射治疗者、综合治疗者的中位生存时间分别为 13、8、7、11个月 ,全组的中位生存期为 8个月 ,生存最长者已达 12 7个月。 1、2、3、4、5年生存率分别为 42 .5 %、15 .5 %、12 .9%、11.1%、10 .9%。结论 病变长度是影响预后因素之一。对于食管小细胞未分化癌 ,应采用综合治疗。手术 +化疗对早期病例可能提高远期疗效
Objective To investigate the clinical features, treatment and prognosis of undifferentiated esophageal small cell carcinoma. Methods A retrospective analysis of 75 patients with esophageal small cell undifferentiated carcinoma was performed. There were 58 males and 17 females. There were 2 cases of cervical esophagus, 11 cases of upper thoracic segment, 46 cases of mid-thoracic segment and 16 cases of lower thoracic segment. In 37 cases, the tumor length was ≤ 5cm and 38 cases were >5cm. 16 cases (2 1.3%) were treated with surgery alone, 5 cases (6.7%) were treated with chemotherapy alone, 4 cases (5.3%) were treated with radiation alone, 32 cases (42.6%) were treated with surgery and chemotherapy, and chemotherapy and radiation therapy were used. Fourteen patients (18.0 %) had surgery + chemotherapy plus radiation therapy in 4 (5.3%). RESULTS: The median survival time was 13, 8, 7 and 11 months for patients who underwent surgery alone, chemotherapy alone, radiotherapy alone, and comprehensive therapy. The median survival time was 8 months for the entire group. It has reached 12 7 months. The 1, 2, 3, 4, and 5 year survival rates were 42.5%, 15.5%, 12.9%, 11.1%, and 10.9%, respectively. Conclusion The length of the lesion is one of the factors that influence the prognosis. For esophageal small cell undifferentiated carcinoma, comprehensive treatment should be used. Surgery + chemotherapy may improve long-term outcome in early cases