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目的 :探讨直肠癌术前动脉灌注化疗的远期疗效。方法 :将 75例可切除直肠癌患者 ,随机双盲分为根治性切除加术前动脉灌注化疗组 (研究组 38例 )和单纯根治性切除术组 (对照组 37例 )。两组患者除研究组在根治术前行动脉灌注化疗 ( FAM方案 )外 ,其它辅助治疗相同 ,密切随访 ,观察患者术后复发、转移及生存情况。结果 :研究组局部复发和肝转移发生率均明显低于对照组 ,其术后 3、5、1 0年生存率也显著高于对照组。结论 :对直肠癌患者进行术前动脉灌注化疗 ,可有效地降低局部复发和肝转移发生率 ,提高生存率
Objective: To investigate the long-term efficacy of preoperative arterial infusion chemotherapy for rectal cancer. Methods: Seventy-five patients with resectable rectal cancer were randomly divided into two groups: radical resection combined with preoperative arterial infusion chemotherapy (study group 38 cases) and simple radical resection group (control group 37 cases). All the patients in the two groups except the study group underwent arterial infusion chemotherapy (FAM) before radical surgery. The other adjuvant treatments were the same and were followed up closely to observe the recurrence, metastasis and survival of the patients. Results: The incidences of local recurrence and hepatic metastasis in study group were significantly lower than those in control group. The survival rates in 3, 5 and 10 years after operation were also significantly higher than those in control group. Conclusion: Preoperative arterial infusion chemotherapy for patients with rectal cancer can effectively reduce the incidence of local recurrence and liver metastasis and improve the survival rate