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目的探讨急性脑梗死(ACI)患者血清白介素-6(IL-6)及高敏C反应蛋白(hs-CRP)的含量水平与颈动脉斑块稳定性之间的关系。方法颈动脉超声法将106例经头部CT/MRI确诊的脑梗死患者分为无斑块组、斑块易损组和斑块稳定组,采用增强免疫比浊测量法检测患者血清中hs-CRP水平,以酶联免疫吸附法检测IL-6水平。结果 106例ACI患者中,83例检出斑块,检出率为78.3%。83例患者斑块多分布于左颈总动脉,其次为左颈动脉分叉处及右颈动脉分叉处;斑块易损组血清hs-CRP、IL-6浓度依次为(7.7±3.8)μg/ml、(97.6±20.4)pg/ml,显著高于斑块稳定组和无斑块组(P均<0.05)。结论血清hs-CRP、IL-6与动脉粥样硬化斑块的不稳定性关系密切,对评估病情与预后具有一定意义。
Objective To investigate the relationship between levels of serum interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) and carotid plaque stability in patients with acute cerebral infarction (ACI) Methods 106 patients with cerebral infarction diagnosed by CT / MRI were divided into two groups: non-plaque group, plaque-vulnerable group and plaque-stabilized group by carotid ultrasonography. The levels of hs- CRP levels were measured by enzyme-linked immunosorbent assay IL-6 levels. Results Of the 106 patients with ACI, 83 were detected plaques, the detection rate was 78.3%. 83 cases of patients with plaque distribution in the left common carotid artery, followed by the left carotid bifurcation and the right carotid bifurcation; plaque vulnerability group of serum hs-CRP, IL-6 concentrations were (7.7 ± 3.8) μg / ml and (97.6 ± 20.4) pg / ml, respectively, which were significantly higher than those of plaque stabilization group and no plaque group (all P <0.05). Conclusion Serum hs-CRP and IL-6 are closely related to the instability of atherosclerotic plaque, which is of great significance for the evaluation of disease and prognosis.