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泡沫细胞的来源和形成是动脉粥样硬化(AS)发病机制的关键问题之一。细胞化学和超微结构分析证实细胞来源有二:即平滑肌细胞(SMC)和单核巨噬细胞(Mφ)。八十年代初我室较为系统的研究了N-VLDL使巨噬细胞转变为泡沫细胞的机理,对于平滑肌细胞摄取N-
The origin and formation of foam cells is one of the key issues in the pathogenesis of atherosclerosis (AS). Cytochemistry and ultrastructure analysis confirmed that there are two sources of cells: smooth muscle cells (SMC) and mononuclear macrophages (Mφ). In the early 1980s, the mechanism of N-VLDL in transforming macrophages into foam cells was systematically studied in our laboratory. For the smooth muscle cells uptake of N-