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合成前列腺素的方法,存在着一个不易克服的困难,就是如何使反应成为立体有择性的(Stereospecific),以便获得立体定向的产物。这一问题,现已由美国新杰西州罗氏药厂化学研究部的一些科学家予以解决。他们的合成方法的关键,在于采用了一个不对称硼氢化反应,这样,就可制成两个立体定向的前列腺素前体,最终导致前列腺素F_2α的合成。这一新的合成方法,以环戊-烯为起起始原料,先加入氢氧化钠,然后在-78℃下,使与溴乙
There is an insurmountable difficulty in the method of synthesizing prostaglandins, which is how to make the reaction stereospecific in order to obtain a stereospecific product. This problem has now been solved by some scientists at the Roche Pharmaceutical Research Division in New Jersey, New Jersey. The key to their approach to synthesis is the use of an asymmetric hydroboronation reaction, so that two stereospecific prostaglandin precursors can be made, eventually leading to the synthesis of prostaglandin F_2α. This new synthesis, starting from cyclopent-ene starting material, first added sodium hydroxide, and then at -78 ° C, and B