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目的 比较三种粘弹剂 (其胜、HelaonGV和DuoVisc)在白内障超声乳化手术中对角膜内皮细胞的保护作用。方法 选择北京同仁眼科中心老年性白内障患者 58人 ,共 70只眼 ,按选用的粘弹剂不同 ,随机分为三组 :其胜组、HelaonGV组和DuoVisc组 ,均采用乳化劈裂技术乳化晶状体核 ,植入折叠人工晶状体。术前、术后 1周、术后 4周和 1 2周测量角膜内皮细胞计数 ,采用F检验进行统计学分析。结果 术前各组角膜内皮细胞计数无差异。术后 1周、 4周和 1 2周角膜内皮细胞计数与其胜组比较 ,HealonGV组差异显著 (P <0. 0 5) ,DuoVisc组差异非常显著 (P <0 . 0 1 )。术后 1周 ,DuoVisc组的角膜内皮细胞平均计数高于HealonGV组 ,差异显著 (P <0 . 0 5)。结论 白内障超声乳化手术中DuoVisc和HelaonGV均具有较好的角膜内皮细胞保护作用 ,其胜的保护作用稍差。DuoVisc更有利于术后早期角膜内皮细胞的恢复。
Objective To compare the protective effect of three kinds of viscoelastics (Sheng, HelaonGV and DuoVisc) on corneal endothelial cells during cataract phacoemulsification. Methods A total of 58 eyes of 70 patients with age-related cataract in Beijing Tongren Eye Center were enrolled in this study. They were randomly divided into three groups according to their choice of viscoelastics: Qinsheng group, HelaonGV group and DuoVisc group. All patients were subjected to phacoemulsification Nuclear, implantation of folded intraocular lens. Corneal endothelial cell counts were measured preoperatively, 1 week after surgery, 4 weeks after surgery and 12 weeks after surgery. Statistical analysis was performed by F test. Results There was no difference in corneal endothelial cell count before operation. The number of corneal endothelial cells at 1 week, 4 weeks and 12 weeks after operation were significantly different from those in HealonGV group (P <0.05). The difference was significant in DuoVisc group (P <0.01). The average corneal endothelial cell count in DuoVisc group was significantly higher than that in HealonGV group at 1 week after operation (P <0.05). Conclusions Both DuoVisc and HelaonGV have better protective effect on corneal endothelial cells in phacoemulsification with less protective effect. DuoVisc is more conducive to the recovery of early postoperative corneal endothelial cells.