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目的总结肺硬化性血管瘤(PSH)的流行病学,病理组织起源、特征与分类,临床表现及治疗、预后情况。方法回顾性总结及分析1999年至2011年收治的32例PSH的发病情况、临床病理特点、诊治方法及预后。对32例标本行免疫组化染色,分析其组织起源。结果 (1)全组32例,其中男性7例(21.88%),女性25例(78.12%);平均年龄40.13岁。(2)32例中无临床症状患者18例(56.25%);咳嗽13例(40.63%),其中咯血10例;胸痛4例(12.50%)。(3)全组均采用手术治疗,术后近期恢复顺利无并发症发生。(4)免疫组化结果证实PSH起源于上皮组织。(5)出院后32例获随访1月～5年,平均2.6年,均无复发及转移。结论 PSH以中青年女性多见,多为体检发现。免疫组化结果提示PSH起源于上皮组织。术前诊断困难,确诊主要依靠病理学检查。手术是PSH的有效治疗方法。
Objective To summarize the epidemiology, pathogenesis, characteristics and classification of pulmonary sclerosing hemangioma (PSH), clinical manifestation, treatment and prognosis. Methods The incidence, clinical and pathological features, diagnosis and treatment of 32 cases of PSH admitted from 1999 to 2011 were retrospectively analyzed and analyzed. 32 cases of specimens of immunohistochemical staining, analysis of the origin of the organization. Results (1) The whole group consisted of 32 patients, including 7 males (21.88%) and 25 females (78.12%) with an average age of 40.13 years. (2) There were 18 cases (56.25%) without clinical symptoms in 32 cases, 13 cases (40.63%) with cough, 10 cases with hemoptysis and 4 cases (12.50%) with chest pain. (3) All the patients were treated by surgery, and no complications occurred after the recent operation. (4) Immunohistochemical results confirmed that PSH originated in epithelial tissue. (5) After discharge, 32 patients were followed up for 1 month to 5 years with an average of 2.6 years without recurrence and metastasis. Conclusion PSH is more common in young and middle-aged women, mostly for physical examination. Immunohistochemistry results suggest that PSH originated in epithelial tissue. Preoperative diagnosis difficult, confirmed mainly rely on pathological examination. Surgery is an effective treatment for PSH.