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现就我院1983年至1986年收治的79例药源性溶血性贫血分析如下。临床资料:本组男63例,女16例。1岁以内46例,～12岁33例,1岁以内的患病率占58.2%。2次以上发病者1例,同家族兄弟先后患病者2例。原发疾病为肠炎21例,菌痢17例,上感22例,支气管炎11例,肺炎5例,胃炎、肝炎、中耳炎各1例。致病药物主要为:痢特灵、解热镇痛药类及磺胺类药物。临床表现主要为血管内溶血症状,多在1～3天内迅速出现严重贫血,其中中度(Hb<90g/L)15例(18.9%),重度(<60g/L)50例(63.3%),极重度(<30g/L)14例(17.7%)。伴有轻度或中度黄疸46例(58.2%);尿呈酱油样或浓茶样(血红蛋白尿)70例(88.6%); 发热71例(89.9%);肝及/或脾脏肿大(>2cm)28例(35.4%)。本组病例诊断依据:①有明确的用药史;②急骤发病,有典型的溶血危象,迅速出现贫血;③实验室检查
Now on our hospital from 1983 to 1986 admitted to 79 cases of drug-induced hemolytic anemia analysis is as follows. Clinical data: The group of 63 males and 16 females. 46 cases were within 1 year of age, and 33 cases were ~ 12 years old. The prevalence rate within 1 year of age accounted for 58.2%. 1 case of more than 2 times the incidence, with the same brothers have two cases of illness. The primary disease was 21 cases of enteritis, 17 cases of bacillary dysentery, 22 cases of upper flu, 11 cases of bronchitis, 5 cases of pneumonia, 1 case of gastritis, hepatitis and otitis media. Pathogenic drugs mainly: furazolidone, antipyretic analgesics and sulfa drugs. Fifteen patients (18.9%) were moderate (Hb <90g / L) and 50 patients (63.3%) were severe (<60g / L) with severe anemia. , Very severe (<30g / L) in 14 cases (17.7%). There were 46 cases (58.2%) with mild or moderate jaundice, 70 cases (88.6%) with soy sauce or concentrated tea sample (hemoglobinuria), 71 cases (89.9%) with fever, enlarged liver and / or spleen > 2cm) 28 cases (35.4%). The diagnosis of this group of patients based on: ① a clear history of medication; ② sudden onset, there are typical hemolysis crisis, rapid anemia; ③ laboratory tests