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应用放免法测定27例肾小球疾病患儿血浆内皮素（ET）、24小时尿ET及ET廓请率（CET）。急性期患儿血浆ET、尿ET及CET显著高于正常儿童，其中，血浆ET与内生肌酐廓清率（Ccr）呈负相关，尿ET与尿β2-微球蛋白呈正相关。缓解期患儿血浆ET、尿ET及CET有所下降。结果表明血浆ET、尿ET及CET可作为反映肾脏损伤的一个敏感指标。
Application of radioimmunoassay in 27 cases of glomerular disease in children with plasma endothelin (ET), 24-hour urinary ET and ET application rate (CET). Plasma ET, urinary ET and CET in children with acute phase were significantly higher than those in normal children. Plasma ET was negatively correlated with endometrial creatinine clearance rate (Ccr), urinary ET was positively correlated with urine β2-microglobulin. The remission of plasma ET, urinary ET and CET decreased. The results show that plasma ET, urinary ET and CET can be used as a sensitive indicator of kidney damage.