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目的了解中山市出生缺陷的发生及分布情况,及时发现影响出生缺陷的可疑因素,协助指导制定相应的干预措施,做好今后出生缺陷监控工作提供科学依据。方法对2008年-2010年中山市各医院分娩的孕满28周～产后7天内出生的所有围产儿(包括活产、死胎、死产)进行出生缺陷监测,并对其发生率、顺位及诊断依据进行分析。结果三年内中山市出生缺陷发生率为260.05/万,排位前五位分别是先天性心脏病、多指(趾)、马蹄内翻足、地中海贫血、总唇腭裂。中山市户籍人口和农村、流动人口的顺位和发生率有明显差异。结论加强流动人口孕产妇的孕期保健管理,普及孕期产前筛查意识,提高出生缺陷产前筛查和产前诊断的准确性,早期发现,早期诊断,早期干预,预防性用药等可减少出生缺陷的发生
Objective To find out the occurrence and distribution of birth defects in Zhongshan City and find out the suspicious factors that affect birth defects in a timely manner to help guide the development of appropriate interventions and provide a scientific basis for the future monitoring of birth defects. Methods To monitor the birth defects of all perinatal infants (including live births, stillbirths and stillbirths) born within 28 weeks after delivery and within 7 days after delivery in all hospitals of Zhongshan City from 2008 to 2010. The incidence, Diagnostic basis for analysis. Results The incidence of birth defects in Zhongshan City was 260.05 / 000 within three years. The top five were congenital heart disease, multiple finger (toe), clubfoot, thalassemia, and total cleft lip and palate. There is a clear difference between the census register population and the rural population in Zhongshan City. CONCLUSIONS: Strengthening pregnant women’s health care management during floating population, popularizing prenatal screening awareness during pregnancy, improving the accuracy of prenatal screening and prenatal diagnosis of birth defects, early detection, early diagnosis, early intervention and preventive medication can reduce birth The occurrence of defects