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目前世界上有1/3的人感染有结核菌,但有90％没有临床症状。感染结核菌后巨噬细胞分泌IL-12,激活Ⅰ型反应淋巴细胞分泌IL-2、ITF-γ。适当的Ⅰ型反应对于有效地消灭结核菌是很重要的。然而,Ⅱ型反应的特点是分泌IL-4、IL-5、IL-6、IL-10、TL-13及IgE。通常肠寄生虫感染或特应原者可引起Ⅱ型反应。Ⅰ型和Ⅱ型反应细胞可相互制约,如ITF-γ可抑制Ⅱ型反应,IL-4可抑制Ⅰ型反应。结核菌皮肤试验属于Ⅰ型反应,而IgE产生属于Ⅱ型反应。Adam等为探讨感染结核菌后是否出现Ⅰ型反应增强和IgE降低,当
At present, one third of the people in the world are infected with TB, but 90% have no clinical symptoms. After infected with Mycobacterium tuberculosis, macrophages secrete IL-12 and activate type I reactive lymphocytes to secrete IL-2 and ITF-γ. The proper type I response is important for the effective elimination of M. tuberculosis. However, type II reactions are characterized by the secretion of IL-4, IL-5, IL-6, IL-10, TL-13 and IgE. In general, enteric parasites infection or atopic origin can cause type II response. Type I and type II reaction cells can be mutually restricted, such as ITF-γ can inhibit type Ⅱ response, IL-4 can inhibit type Ⅰ reaction. Mycobacterium tuberculosis skin test belongs to type Ⅰ reaction, and IgE production belongs to type Ⅱ reaction. Adam et al in order to explore whether there is enhanced type I response and IgE decrease after TB infection