Value of c-Met for Predicting Progression of Precancerous Gastric Lesions in Rural Chinese Populatio

• 作 者: Yu Sun Meng-meng Tian Li-xin Zhou Wei-cheng You Ji-you Li
• 机 构: Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Department of Pa
• 出 处: 中国癌症研究（英文版）
• 发表日期: 2012年1期
• 关键词: c-Met Intestinal metaplasia Dysplasia Follow-up

Objective:To investigate the value of c-Met in predicting progression of precancerous gastric lesions.Methods:A population-based study was conducted to detect the overexpression of c-Met by immunohistochemical analysis in 124 subjects with precancerous gastric lesions.Odds ratio (OR) and 95％ confidence interval (95％ Cl) were calculated for the association of c-Met overexpression with the risk of advanced gastric lesions.Results:The positive rates of c-Met were 55.7％ in intestinal metaplasia (IM) and 64.8％ in dysplasia (DYS),respectively.Stratified analysis indicated that the proportion of c-Met overexpression was 71.4％ for IM progressive group,significantly higher than that for IM persistent group (40.0％,P＜0.05).Compared to the IM persistent group,unconditional logistic regression showed that OR of c-Met overexpression for the IM progressive group was 7.416 (95％ Cl:2.084-26.398).Conclusion:c-Met plays an important role in gastric carcinogenesis.Detection of c-Met is of value in predicting progression of precancerous gastric lesions from IM to DYS.