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目的探讨亚洲人群中谷胱甘肽S-转移酶(GSTT1)的基因多态性与结直肠癌遗传易感性的关联关系。方法采用Meta分析方法进行合并效应值分析及异质性分析,并根据试验设计不同进行亚组分析。结果 GSTT1的空白基因型是结直肠癌发生的危险因素。结论在亚洲人群中,GSTT1的基因多态性与结直肠癌的遗传易感性相关。
Objective To investigate the association between glutathione S-transferase (GSTT1) gene polymorphism and genetic susceptibility to colorectal cancer in Asian population. Methods Meta-analysis was used to analyze the effect of combined effect and heterogeneity, and subgroup analysis was conducted according to the experimental design. Results The blank genotype of GSTT1 was a risk factor for colorectal cancer. Conclusions In Asian populations, the genetic polymorphism of GSTT1 is associated with the genetic susceptibility to colorectal cancer.