Stathmin is highly expressed in eutopic endometrium of patient with endometriosis

• 作 者: 刘海元 郎景和 刘珠凤 朱兰 冷金花 孙大为 樊庆泊
• 机 构: Department of Obstetrics & Gynecology,Peking Union Medical College Hospital,Peking Union Medical Col
• 出 处: 生殖医学杂志
• 发表日期: 2009年S2期
• 关键词: endometriosis endometrial glandular proliferative pathogenesis adenomyosis women

Objective:To investigate the expression of stathmin in eutopic endometrium of women with or without endometriosis. Methods:The eutopic endometrium samples were collected from thirty-six women with endometriosis and nineteen age-matched women without endometriosis.The expression of stathmin protein was detected by immunohisto-chemistry and Western blot. Results:Stathmin was expressed in both endometrial glandular and stromal cells throughout the menstrual cycle.Stathmin expression had no significant difference between proliferative and secretory phase.Stathmin was overexpressed in eutopic endometrium of women with endometriosis compared with those without endometriosis. Conclusion:The overexpressed stathmin in endometrium of patient with endometriosis may play a certain role in the pathogenesis of endometriosis.

Objective: To investigate the expression of stathmin in eutopic endometrium of women with or without endometriosis. Methods: The eutopic endometrium samples were collected from thirty-six women with endometriosis and nineteen age-matched women without endometriosis. The expression of stathmin protein was detected by Results: Stathmin was expressed in both endometrial glandular and stromal cells throughout the menstrual cycle. Stathmin expression had no significant difference between proliferative and secretory phases. Stathmin was overexpressed in eutopic endometrium of women with endometriosis compared with those without Conclusion: The overexpressed stathmin in endometrium of patient with endometriosis may play a certain role in the pathogenesis of endometriosis.