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改善胰岛素抵抗以及血运重建治疗冠心病是否改善2型糖尿病合并冠心病患者的预后是尚须解决的临床问题。新近发表在新英格兰杂志的BARI2D研究显示,对于2型糖尿病合并病情稳定的冠心病患者,在5年观察期内没有体现血运重建术的价值;改善胰岛素抵抗在降低心血管疾病发生率和病死率方面并不优于增加胰岛素水平的治疗。
Improving insulin resistance and whether revascularization in coronary artery disease improves the prognosis of patients with type 2 diabetes mellitus complicated with coronary heart disease is a clinical issue yet to be resolved. The recently published BARI2D study in the New England Journal showed no benefit of revascularization for type 2 diabetes mellitus with stable coronary heart disease over a five-year period; improving insulin resistance in reducing cardiovascular morbidity and mortality Rates are not superior to those that increase insulin levels.