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[目的]探讨介入联合同期放化疗治疗局部晚期鼻咽癌的疗效。[方法]收集108例初治局部晚期鼻咽癌患者(Ⅲ～Ⅳa期),分为介入联合同期放化疗组(研究组)以及同期放化疗组(对照组)。观察并比较两组的近、远期疗效和不良反应。[结果]研究组与对照组的治疗总有效率分别为92.7%和79.2%,差异有统计学意义(P=0.04)。研究组3年生存率为98.2%,对照组为96.2%;3年复发率分别为9.1%与17.0%,远处转移率分别为5.5%与13.2%,差异均无统计学意义(P>0.05)。两组急性不良反应比较亦无显著性差异。[结论]介入联合同期放化疗治疗局部晚期鼻咽癌,对比同期放化疗,近期疗效有所提高,急性不良反应相似。
[Objective] To investigate the efficacy of concurrent radiotherapy and chemotherapy in the treatment of locally advanced nasopharyngeal carcinoma. [Method] A total of 108 patients with newly diagnosed locally advanced nasopharyngeal carcinoma (Ⅲ ~ Ⅳa stage) were enrolled and divided into the interventional radiotherapy and chemotherapy group (study group) and the concurrent chemoradiotherapy group (control group). Observed and compared the two groups of short-term, long-term efficacy and adverse reactions. [Results] The total effective rates of treatment group and control group were 92.7% and 79.2%, respectively, with significant difference (P = 0.04). The 3-year survival rate was 98.2% in the study group and 96.2% in the control group. The 3-year recurrence rates were 9.1% and 17.0%, and the distant metastasis rates were 5.5% and 13.2% respectively, with no significant difference (P> 0.05 ). No significant difference between the two groups of acute adverse reactions. [Conclusion] Interventional radiotherapy and chemotherapy combined with the same period for the treatment of locally advanced nasopharyngeal carcinoma, compared with the same period of radiotherapy and chemotherapy, the recent efficacy has increased, similar to acute adverse reactions.