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目的为了研究机体解毒系统的障碍在帕金森病（ＰＤ）遗传易感性中的作用。方法选择确诊的ＰＤ病人和年龄、性别基本匹配的正常人各１００名，分离白细胞ＤＮＡ，利用聚合酶链反应检测解毒酶谷胱甘肽转移酶μ（ＧＳＴＭ）基因突变率，并分析比较ＰＤ病人与正常人之间多态性频率的差异。结果发现ＧＳＴＭ无效基因（ＧＳＴＭ０型）使患ＰＤ的危险性提高１５３倍。结论提示解毒酶ＧＳＴＭ０基因缺陷可能是ＰＤ遗传易感性的一个原因。
Purpose To investigate the role of the body’s detoxification system in the genetic predisposition to Parkinson’s disease (PD). Methods 100 patients diagnosed with PD and 100 normal matched persons of age and gender were selected. Leukocyte DNA was isolated and the mutation rate of glutathione transferase μ (GSTM) gene was detected by polymerase chain reaction Differences in the frequency of polymorphisms with normal subjects. The results showed that the GSTM null gene (GSTM0 type) increased the risk of PD by 153 times. The conclusion suggests that detoxification enzyme GSTM0 gene defect may be a reason of genetic susceptibility to PD.