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目的了解儿童泌尿系统肠球菌的分布特点及对药物的敏感性,指导临床合理用药。方法分析广州市妇女儿童医疗中心儿童院区肾内科2011年1月至2014年12月中段尿培养肠球菌阳性患儿的临床资料及药敏试验结果。结果 82株肠球菌属中屎肠球菌53株,占64.6%,粪肠球菌29株,占35.4%。屎肠球菌对替加环素、万古霉素、喹奴普汀/达福普汀、利奈唑胺敏感,粪肠球菌对替加环素、万古霉素,呋喃妥因、利奈唑胺、喹诺酮类及青霉素类敏感。万古霉素耐药的屎肠球菌和粪肠球菌的检出率分别为1.9%和3.4%。结论纳入儿童中段尿培养分离的肠球菌以屎肠球菌为主;不同种属的肠球菌有不同的临床特点;肠球菌对万古霉素有较好的敏感性;应注意其条件致病菌的特点。
Objective To understand the distribution characteristics of urinary enterococci in children and its sensitivity to drugs to guide clinical rational drug use. Methods The clinical data and drug susceptibility test results of urine culture enterococci positive children from January 2011 to December 2014 in Children’s Hospital of Guangzhou Children’s Medical Center were analyzed. Results Enterococcus faecium was found in 82 Enterococcus spp., Accounting for 64.6% and Enterococcus faecalis, accounting for 35.4%. Enterococcus faecalis is highly sensitive to tigecycline, vancomycin, quetiapine / dalfopristin, linezolid, fecal enterococci for tigecycline, vancomycin, nitrofurantoin, linezolid, quinolones and Penicillins sensitive. The detection rates of vancomycin-resistant Enterococcus faecalis and Enterococcus faecalis were 1.9% and 3.4% respectively. Conclusions Enterococcus faecalis isolated from urinary culture in middle children is dominated by Enterococcus faecium. Different species of enterococci have different clinical features; Enterococcus has good sensitivity to vancomycin; attention should be paid to its pathogenic bacteria Features.