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Porous hybrid microspheres were fabricated by the synthesizedcalcium gluconate-g-poly(D,L-lactide)(CG-gPDLLA) composites. These hybrid microspheres were treated with analkaline solution for different period of time to controltheamount of generated carboxylate groups and remained CG on the surface.The microspheres were then incubated in a supersaturated simulated body fluid(1.5SBF)solution for differenttime to investigate their biomimetic mineralization behavior. The depositions were found to have a fine cluster morphology, a similar crystal structure and chemical structure to natural hydroxyapatite, and a medium Ca/P of approximately 1.30. The effect of surface treating time on the structure and mineralization behavior of these microspheres has been discussed in detail. The results indicatethat the nucleation and growth of apatite on the surfaceare influenced bytheinduced carboxylate groups and the remained CG. The hybrid CG-g-PDLLA microspheres have the potential as anovel alternativein bone tissue engineering.
Porous hybrid microspheres were fabricated by the synthesizedcalcium gluconate-g-poly (D, L-lactide) (CG-gPDLLA) composites. These hybrid microspheres were treated with analkaline solution for different period of time to control the amount of generated carboxylate groups and remained CG on the surface. microspheres were then incubated in a supersaturated simulated body fluid (1.5SBF) solution for differenttime to investigate their biomimetic mineralization behavior. The depositions were found to have a fine cluster morphology, a similar crystal structure and chemical structure to natural hydroxyapatite, and a medium Ca / P of approximately 1.30. The effect of surface treating time on the structure and mineralization behavior of these microspheres has been discussed in detail. The results indicate that the nucleation and growth of apatite on the surface of influenced by the induced carboxylate groups and the remained CG. The hybrid CG-g-PDLLA microspheres have the potential as anovel alternative in bone tissue engineering.