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目的探讨支气管镜介入辅助治疗配合全身抗结核治疗对耐多药空洞肺结核(MDR—PTB)的治疗效果。方法将60例耐多药空洞肺结核患者随机分为治疗组(30例)和对照组(30例),两组均采用3DVAE克拉/15DVE克拉全身抗结核治疗,治疗组强化期每周经支气管镜治疗1次,共5～8次,然后比较两组的临床疗效。结果治疗3、6个月时,在痰菌阴转率、病灶吸收率(显著吸收+吸收)、空洞缩小或闭合率方面两组比较差异有显著性(P<0.05)。结论经支气管镜介入辅助治疗配合全身抗结核治疗耐多药空洞肺结核,疗效显著优于单纯全身抗结核治疗,其有促使痰菌阴转、病灶吸收及空洞缩小或闭合的作用。
Objective To investigate the therapeutic effect of bronchial interventional therapy combined with systemic antituberculous therapy on multidrug-resistant tuberculosis (MDR-PTB). Methods Sixty patients with multi-drug-resistant pulmonary tuberculosis were randomly divided into treatment group (30 cases) and control group (30 cases). Both groups were treated with 3DVAE carat / 15DVE carat total anti-TB therapy. Treatment 1, a total of 5 to 8 times, and then compare the clinical efficacy of the two groups. Results At 3 and 6 months of treatment, there was significant difference between sputum negative conversion rate, lesion absorption rate (significant absorption + absorption), cavity shrinkage or closure rate (P <0.05). Conclusions The bronchial interventional therapy combined with systemic antituberculosis treatment of multi-drug-resistant tuberculosis tuberculosis significantly better than simple systemic antituberculous therapy, which has the role of promoting sputum negative conversion, lesion absorption and cavity shrinking or closing.