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自1961年Sekiguchi和Obi首次报道了固体分散物(Solid Dispersions)后,近30年来,药学工作者利用固体分散技术,在增加难溶性药物溶出速度和生物利用度方面进行了大量工作,迄今为止,发表的论文超过300余篇,研究的药物百余种,应用的载体30多种。近几年又利用固体分散技术,采用肠衣材料,研究口服的缓释和控释制剂,如硝苯啶,潘生丁、地高辛用肠溶性包衣材料,以溶剂方法制备的缓释颗粒。有关固体分散物的概念、特点、分类、制法及提高难溶性药物溶出速度的机理等已有报道,本文仅对目前固体分散物最常用的载体——聚合物载体——聚乙二醇类和聚氧乙烯吡咯烷酮类载体的特点和应用加以综述。
Since the first report by Sekiguchi and Obi in 1961 on Solid Dispersions, pharmacologists have used solid dispersion techniques for much of the past 30 years in increasing the rate of dissolution and bioavailability of poorly soluble drugs. To date, Published more than 300 papers, a study of more than 100 kinds of drugs, application of more than 30 kinds of vectors. In recent years, the use of solid dispersion technology, the use of enteric-coated materials, the study of oral sustained-release and controlled release formulations, such as nifedipine, dipyridamole, digoxin with enteric coating materials, solvent-based sustained-release granules. The concept, characteristics, classification, manufacturing method and mechanism of improving the dissolution rate of insoluble drugs have been reported in this paper. In this paper, only the most commonly used carriers for solid dispersions - polymer carrier - polyethylene glycol And polyoxyethylene pyrrolidone carrier characteristics and applications are reviewed.