基于数据挖掘探讨中药治疗克罗恩病的用药规律

• 作 者: 曾程 游绍伟 王文素 何典城
• 机 构: 贵州中医药大学，贵阳 550025;贵州中医药大学第二附属医院，贵阳 550003
• 出 处: 国际医药卫生导报
• 发表日期: 2022年5期
• 关键词: Crohn's disease Chinese medicine Medication rules Data mining

目的:探讨中医药治疗克罗恩病的用药规律，为临床用药及相关机制研究提供新的思路。方法:按照纳入和排除标准，收集2009—2020年治疗克罗恩病方剂，并建立网络数据库，对数据进行频次、频率、关联规则分析。结果:此次共收集方剂126首，涉及中药共166种，高频中药为白术（49.2%）、茯苓（42.9%）、白芍（33.3%）、当归（27.8%）等18种，以健脾利湿、理气活血为主，四气以温（46.0%）、寒（24.0%）、平（23.0%）为主，五味以甘（33.0%）、苦（30.0%）、辛（25.0%）为主，归经以脾经（频率为790）为最。结论:治疗克罗恩病大多以健脾利湿、理气活血为主，重要归经是脾、胃、肺，核心药对是茯苓、白术、白芍、陈皮。药物配伍上体现了从脾论治、肺与大肠相表里等治疗思想，同时加入镇静、调情志的药物。“,”Objective:To explore the medication rules of traditional Chinese medicine in the treatment of Crohn\'s disease, and to provide new ideas for clinical medication and related mechanism research.Methods:According to the inclusion and exclusion criteria, Crohn\'s disease prescriptions were collected; the network database was established; and the frequency, rate, and association rules of the data were analyzed.Results:A total of 126 prescriptions were collected, involving 166 kinds of traditional Chinese medicine; 18 kinds of which in the high frequency were atractylodis atractylodis (49.2%), Poria cohoe (42.9%), paeoniae alba (33.3%)), Angelica (27.8%), etc., which were mainly for invigorating spleen, promoting dampness, regulating qi, and promoting blood circulation. The four qi mainly were warm (46.0%), cold (24.0%), and flat (23.0%). The five tastes mainly were sweet (33.0%), bitter (30.0%), and acrid (25.0%). The meridian with the highest frequency (790) was spleen.Conclusions:In the treatment of Crohn\'s disease, the main drugs are invigorating spleen and dampness, regulating qi, and promoting blood circulation. The main meridians are spleen, stomach, and lung. The main drugs are Poria cohoe, atractylodis atractylodis, paeoniae alba, and tangerine bark. The drug compatibility reflects the treatment ideas from the signs and mechanism of spleen, lung, and large intestine, with addition of sedation and mood modulation drugs.