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延胡索素乙(簡称乙素)是中药延胡索(Corydalis ambigua)有效成分之一,有关的化学工作在1928—1936年间已有研究,其結构式确定为四氫巴馬汀(dl-Tetrshydropalmatinc)(Ⅰ)。乙素的药理作用虽然有人研究过,但是它的鎮痛作用为我們首先发現,其鎮痛指数比延胡索素甲、丑为高,并且不容易产生耐药性。它对麻醉猫或清醒家兔血压和呼吸的影响要比吗啡类鎮痛药为輕微,对高級神經活动具有选择性的抑制作用。这些資料都說明乙素是一个有价值的中枢抑制剂。为了便于过渡临床試用,故进行有关的毒性研究,并进一步对乙素的中枢神經系統的药理作用作了較全面的分析。
Tetrahydropalmatine (hereinafter referred to as B) is one of the active ingredients of Corydalis ambigua. The related chemical work has been studied from 1928 to 1936 and the structural formula was determined as dl-Tetrshydropalmatinc ( Ⅰ). Although pharmacological effects of B have been studied, but its analgesic effect for the first time we found that its analgesic index than the fumaric acid, ugly high, and not prone to drug resistance. It is anesthetized cats or sober rabbits blood pressure and respiration than morphine analgesics for mild, selective inhibition of advanced nerve activity. These data indicate that B is a valuable central inhibitor. In order to facilitate the transition clinical trial, so the toxicological studies carried out, and further on the pharmacological effects of B central nervous system made a more comprehensive analysis.